- Jawline Treatment with Hyaluronic Acid
- Chin Augmentation for Harmonious Facial Features
- Lip Augmentation
- The Russian Lips (Doll-Lips) Technique with Hyaluronic Acid
- Effective Non-Surgical Rhinoplasty: Hyaluronic Acid Application
- Hyaluronic Acid Injection for Nasolabial Folds
- Remove Dark Circles, Tear Troughs & Eye Bags
- Cheek Augmentation – Cheekbone Injections

Polynucleotide Treatment
from €300*
With polynucleotides, you can regenerate and revitalize your skin from within – for more elasticity, moisture, and a youthful glow! This innovative treatment supports cell regeneration, improves skin structure, and reduces fine lines and wrinkles – all without surgery!
Aesthetiqua
Treatment Options with Polynucleotides for Youthful Skin
Pain Scale
Polynucleotide treatment is ideal for anyone who desires younger and more radiant skin. Special active ingredients are injected that specifically stimulate collagen production and simultaneously support skin regeneration.
Through this process, fine lines can be reduced and skin elasticity can be noticeably improved. Thanks to its deeply effective properties, this method helps to tighten the skin structure and achieve a fresh, youthful appearance.
In our practices, we offer polynucleotide treatment, which is individually tailored to each patient’s needs to specifically counteract skin aging. Since it is versatile, it can be applied to various areas of the body, such as the face or décolletage. In this way, the skin is not only visibly regenerated but also strengthened long-term, so that it retains its natural radiance and looks fresher.
In just 2 to 3 sessions, spaced several weeks apart, the skin is deeply regenerated, making the results particularly long-lasting. This innovative method has proven to be not only effective but also safe, which is why it is a popular alternative to classic hyaluronic acid treatment.
Facts
Polynucleotides
Duration
30 Minutes
Longevity
8-12 Months
Pain
1/10
Costs
From €300.00/Session *
*Billed According to Goä
Mesotherapy
Polynucleotide Therapy for a Younger Appearance
What Exactly are Polynucleotides?
Polynucleotides are biodegradable molecules used in aesthetic medicine to support skin rejuvenation. These molecules consist of long chains of nucleotides that stimulate cell regeneration and improve skin quality. Polynucleotides work by stimulating the skin’s natural healing processes, thereby promoting the production of collagen and elastin. These processes are crucial for firm and elastic skin.
Another advantage of polynucleotides is that they accelerate wound healing while strengthening the skin barrier. Thanks to their special formula, they are directly injected into the skin in the form of an injectable gel, enabling targeted and effective treatment.
The high purity of the polynucleotides used ensures that they penetrate the skin safely and efficiently. Therefore, polynucleotides are a promising solution for skin rejuvenation and improving skin appearance.
Procedure of this Innovative Therapy
The polynucleotide treatment procedure is generally straightforward and efficient. First, a detailed consultation with one of our doctors takes place, during which the patient’s individual needs are discussed. Afterward, the skin is cleansed, and if necessary, an anesthetic cream is applied to minimize sensation during the injection. The therapy itself involves injecting the polynucleotide gel into the desired skin areas, which takes only a few minutes and effectively combats skin aging. Furthermore, this innovative therapy is still very new and achieves unparalleled results.
After the injection, slight redness or swelling may occur, but these usually subside quickly. The treatment typically lasts about 30 to 60 minutes, depending on the areas treated. In the following weeks, the skin will continue to benefit from the therapy as collagen production is stimulated and skin regeneration begins. The results of the treatment are often long-lasting, which makes polynucleotide therapy particularly attractive.
A polynucleotide therapy consists of 2-3 sessions every 3 weeks. To maintain the results, a refresher treatment should take place once a year.
Areas of Application of the Therapy
Areas of Application for Polynucleotides with PhilArt
A Common Area of Application is the Delicate Eye Area, as the Skin Here is Particularly Thin and Prone to Redness and Swelling. Thanks to the Targeted Injection of Polynucleotides into this Region, the Skin Structure Can be Sustainably Strengthened and Elasticity Improved Simultaneously. this Slows down Skin Aging, Reducing Fine Lines and Making the Face Look Fresher and more Youthful Overall.

Eye Area
Treatment of the eye area with injectable polynucleotides offers an effective solution for signs of aging such as under-eye bags and wrinkles. This therapy stimulates collagen production and promotes the regeneration of skin cells, leading to firmer and smoother skin. The results are often immediately visible, with the skin around the eyes appearing fresher and more radiant. In addition, side effects are generally mild and temporary, making the treatment an attractive option.
Neck / Décolletage
Another important area of application is the neck and décolletage, where the skin often shows signs of aging. Polynucleotide treatment can be equally effective here by improving skin elasticity and rejuvenating the skin’s appearance. The injection of polynucleotides refines the skin structure and reduces the appearance of fine lines, leading to a significant reduction in skin aging.

Prices
Our Prices
From €300/Session* (Additionally, it should be Noted that 2 - 3 Sessions Spaced Approximately 3 Weeks apart are Recommended to Achieve Optimal Results in the Treatment of Skin Aging. We Exclusively Use Croma Products for this)
* Billed according to GOÄ
Possible Risks and Side Effects
Risks and Side Effects of the Therapy
Although Polynucleotide Treatment is Considered Safe, Risks and Side Effects are Possible, as with any Medical Intervention.
The most common side effects include:
- Redness,
- swelling, and
- small bruises at the injection sites.
These symptoms are usually mild and subside on their own within a few days. It is important to discuss any concerns with the treating physician beforehand.
In rare cases, more severe side effects may occur, such as allergic reactions or infections. Therefore, it is crucial that polynucleotide treatment is performed exclusively by qualified professionals to minimize the risk. Proper aftercare and the use of high-purity polynucleotides can also contribute to the safety and effectiveness of the treatment, allowing patients to achieve the best possible results.
PhilArt Biostimulators at Aesthetiqua – Natural Skin Rejuvenation with Polynucleotides
At Aesthetiqua, we utilize advanced PhilArt technology to enable minimally invasive skin rejuvenation. Unlike conventional hyaluronic acid fillers, which primarily add volume, PhilArt biostimulators work based on polynucleotides. These natural building blocks of DNA possess strong regenerative properties and actively support the skin in its renewal. They promote cell regeneration, improve skin structure, and provide more elasticity as well as a visible reduction in fine lines and wrinkles.
Advantages
Benefits of Polynucleotide Treatment
Polynucleotide treatment offers a variety of benefits for patients of all ages:
- Natural Skin Rejuvenation: Polynucleotides promote the regeneration of skin cells and stimulate collagen production.
- Gentle Wrinkle Reduction: Compared to more invasive procedures, this polynucleotide treatment is gentle and characterized by a short recovery period.
- Long-term Results: The results of polynucleotide treatment improve after each session and are visible over a longer period.
In our practices, we offer polynucleotide treatment with the highest precision and most modern methods. Our experienced doctors professionally guide you from the initial consultation to aftercare, ensuring that the best possible results of the polynucleotide treatment are achieved.
Doctors
Our On-Site Doctors

Björn Frey
Mesotherapy
BJÖRN FREY has many years of experience in the application of polynucleotides and uses them specifically to promote skin regeneration. Through precise injection, the skin structure is visibly improved, giving it more elasticity and moisture. Initial effects are noticeable after just a few weeks, while the final result fully unfolds after about three months.
It is particularly important to BJÖRN FREY that the results appear natural and harmonious and perfectly adapt to each patient’s individual skin condition. Thanks to the polynucleotides used, cell regeneration is activated, connective tissue is strengthened, and the skin is revitalized long-term. This creates a fresh, radiant complexion – all without surgery.

Doctor Sebastian Fromm
Polynucleotides in Mannheim
SEBASTIAN FROMM has many years of experience in aesthetic medicine and offers polynucleotide treatment at locations in Mannheim and Heidelberg. His focus is on targeted skin regeneration to improve skin elasticity and hydration and promote a naturally radiant complexion.
At Aesthetiqua, only high-quality active ingredients are used. The treatment is particularly suitable for patients who wish to visibly rejuvenate their skin structure without surgical intervention. Polynucleotides support cell regeneration, reduce fine lines, and give the skin a fresh, revitalized appearance.

Doctor ALENA SCHWEDE
Polynucleotides
Alena Schwede has many years of experience in aesthetic medicine and manages the Karlsruhe location. There, she offers the innovative polynucleotide treatment, which specifically contributes to skin regeneration and improvement of skin structure. She places particular emphasis on natural and harmonious results that not only revitalize the skin but also sustainably rejuvenate it.
At Aesthetiqua’s practice, only high-quality active ingredients are used. These tested and safe substances help promote cell regeneration, improve elasticity, and intensely moisturize the skin. This creates a fresh, radiant complexion – all without surgical intervention.
FAQ
Frequently Asked Questions about Polynucleotide Treatment
What results can I expect from polynucleotide therapy?
From polynucleotide therapy, you can expect visible improvements in skin structure and elasticity. Since the treatment works deep within the skin, it promotes collagen production and supports cell regeneration. This reduces fine lines, makes the skin firmer, and increases its moisture, giving it a fresh and youthful appearance. The first effects are often visible after just a few weeks, while the final result continues to improve in the following months. Thanks to its long-lasting effect, the skin benefits from more firmness and a healthy glow over a longer period.
Is the therapy suitable for all skin types?
Yes, the therapy is suitable for all skin types, as it is particularly gentle and well-tolerated. Regardless of whether the skin is dry, sensitive, or mature, polynucleotides can specifically help improve skin structure and promote regeneration. In addition, the treatment adapts individually, so it can be tailored to the respective skin needs. Thanks to this versatile applicability, both younger and older skin types benefit from the regenerating effect.
However, individuals with certain skin conditions or allergies should consult a specialist beforehand.
How often should I get a refresher treatment?
The frequency of polynucleotide treatment may vary, but we generally recommend a refresher every 9 to 12 months to maintain the results.
Does the treatment cause pain?
The treatment is generally well-tolerated and causes only minimal pain. Since the injections are performed with very fine needles, the punctures are barely noticeable. If desired, an anesthetic cream can be applied before the treatment to further reduce sensation. Immediately after the treatment, slight redness or swelling may occur, but these quickly subside. Overall, polynucleotide therapy is considered a gentle and mild method that can be performed without extended downtime.
What is the difference between hyaluronic acid and polynucleotides?
The main difference between hyaluronic acid and polynucleotides lies in their mode of action and their goal. Hyaluronic acid fillers are primarily used to build volume and directly fill wrinkles. They bind moisture, thereby providing an immediately visible plumping effect on the skin.
Polynucleotides, on the other hand, work deep within the skin and support cell regeneration as well as collagen and elastin production. Instead of creating volume, they improve skin structure, increase elasticity, and promote natural regeneration. This makes the skin not only firmer and more resilient but also gives it a fresh and youthful appearance.
In summary: While hyaluronic acid provides an immediate lifting effect, polynucleotides offer long-term skin rejuvenation and regeneration.
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