Polynucleotides vs. Hyaluronic Acid: which Treatment is Right for You?

Hyaluronic Acid, Polynucleotides

Do you want to look fresher, reduce wrinkles, or improve your skin’s appearance – but without surgery? Then hyaluronic acid or polynucleotides might be just right for you. But which treatment is better suited? Polynucleotides vs. Hyaluronic Acid?

Both methods offer great results, but they work differently. In this article, we’ll show you the differences, explain the pros and cons – and help you find out which treatment suits you.

Which Treatment is Right for You?

That depends entirely on your skin condition and your goals:

Do you want immediately visible results? → Hyaluronic Acid.
Do you want to improve your skin long-term? → Polynucleotides.
Do you want to combine both? → We often do this. First regeneration, then targeted volume.

Our recommendation: Get professional advice. Our doctors will examine your skin closely and develop an individual treatment plan with you.

Comparison: Hyaluronic Acid vs. Polynucleotides

Criterion	Hyaluronic Acid	Polynucleotides
Goal	Filling, smoothing wrinkles	Skin regeneration, cell repair
Effect	Immediately visible	Visible after 2–4 weeks
Applications	Cheeks, lips, chin, wrinkles	Face, neck, décolletage, eye area
Longevity	6–12 months	Long-term stable, with refreshers
Side effects	Swelling possible	Very well tolerated
Suitable for	Volume building, contour improvement	Skin appearance, moisture, radiance

Polynukleotiden-Behandlung-Mundfältchen-Aesthetiqua

Polynukleotiden-Behandlung-Gesicht-Aesthetiqua

Polynukleotiden-Behandung-Auge-Aesthetiqua

What Does a Hyaluronic Acid Treatment Do?

Hyaluronic acid occurs naturally in your body and is responsible for moisture and elasticity. In aesthetic treatment, it is specifically injected to smooth wrinkles or restore volume – e.g., on the cheeks, lips, or in the nasolabial fold area.

Vorteile:

Immediately visible effect
Naturally appearing volume
Versatile (wrinkles, contours, lips)
Well tolerated

Nachteile:

No regenerating effect – only treats symptoms
Breaks down after a few months
Swelling or lumps possible

Hyaluronic Acid Treatments

Immediate results - no downtime

To Hyaluronic Acid Treatments

What are Polynucleotides – and how Do They Work?

Polynucleotides are short DNA building blocks that stimulate regeneration processes deep within the skin. The skin is not “filled”, but improved from within. Moisture, elasticity, and cell structure visibly increase. Particularly suitable for tired, thin, or sun-damaged skin.

Vorteile:

Lastingly regenerates the skin
Improves structure, moisture, and elasticity
Few side effects – even for sensitive skin
Natural result without volume change

Nachteile:

No immediate effect
Results visible after several treatments (usually 3–4)
Not suitable for targeted volume building

Regenerate skin with polynucleotides

Improved structure and elasticity of your skin

To Polynucleotide Treatment

"Polynucleotides vs. Hyaluronic Acid: Both methods have their strengths. Whether you choose hyaluronic acid or polynucleotides – it's important that the treatment suits you. In our practice, you get both: quick effects, but also sustainable skin improvement. Book your consultation appointment now – and find out how you can support your skin naturally and effectively."

ARZT BJÖRN FREY

Doctor

FAQ

Frequently Asked Questions about: Polynucleotides vs. Hyaluronic Acid

What is better – Hyaluronic Acid or Polynucleotides?

That depends on your treatment goal. If you want to build volume immediately or smooth wrinkles, hyaluronic acid is the better choice. If you want to sustainably improve your skin structure and promote regeneration, polynucleotides are ideal. Often, a combination of both treatments is most effective.

How does the durability of the treatments differ?

Hyaluronic acid usually lasts 4 to 8 months, depending on the area and metabolism. Polynucleotides work slower but have a long-term stabilizing effect on skin quality with regular refreshers.

Can polynucleotides and hyaluronic acid be combined?

Yes, absolutely. Many patients benefit from a combination: polynucleotides improve skin structure from within, while hyaluronic acid provides immediately visible volume. The combination is individually tailored and professionally planned by our doctors.

For which skin types are polynucleotides suitable?

Polynucleotides are particularly well suited for sensitive, mature, sun-damaged, or dry skin. They also show very good results for skin weakened by stress, lack of sleep, or environmental factors.

What are the respective side effects of the treatments?

Both treatments are considered very safe. With hyaluronic acid, swelling, bruising, or small lumps can occur in rare cases. Polynucleotides are very well tolerated and cause hardly any side effects – also ideal for sensitive skin.